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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 323-332 doi: 10.1007/s11684-011-0172-4

Abstract:

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Emerging immunological strategies: recent advances and future directions

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 805-828 doi: 10.1007/s11684-021-0886-x

Abstract: Immunotherapy plays a compelling role in cancer treatment and has already made remarkable progress.developed, such as small molecules, bispecific antibodies, chimeric antigen receptor T cell products, and cancerChimeric antigen receptor T cell products and cancer vaccines have also been investigated.This review explores the recent progress and challenges of different forms of immunotherapy agents and

Keywords： cancer immunotherapy bispecific antibodies small molecules chimeric antigen receptor T therapy cancer

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an important role in the development of cancerimmunotherapy.

Keywords： tumor immunotherapy immune checkpoint inhibitor antibiotics gut microbiota drug–drug interaction

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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1, Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract: cells are key innate immune cells that provide the first line of defense against viral infection and cancerof tumor escape from NK cell recognition, the current status and advanced progress of NK cell-based immunotherapy

Keywords： Natural killer cell Immunotherapy Cancer Clinical trial Chimeric antigen receptor

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4, Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgenceimplemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy

Keywords： vaccine nanoparticle tumor immunotherapy microenvironment

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Radial porous SiO

Chuangnian Zhang, Ying Dong, Jing Gao, Xiaoli Wang, Yanjun Jiang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5, Pages 1296-1311 doi: 10.1007/s11705-020-2034-6

Abstract: Here, we reported a cancer nanovaccine based on SiO nanoflowers with a special radial pore structurepresent results indicated that the nanovaccine can be served as a potential therapeutic vaccine to treat cancer

Keywords： silica nanoflower antigen delivery cancer immunotherapy nanovaccine

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Cervical cancer (CC) is the fourth most commonly diagnosed female malignancy and a leading cause of cancer-related

Keywords： PD-1 PD-L1 immune checkpoint blockade antibody immunotherapy cervical cancer

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Nature Conference

Conference Date: 11 Jun 2019

Conference Place: 中国/山东/青岛

Administered by: 中国免疫学会；《自然-免疫学》；《中国免疫学会英文会刊（细胞与分子免疫学）》

Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1, Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract:

Cancer is a potentially life-threatening disease characterized by the immortalization of tumor cellsImmunotherapy has recently gained increasing interest among researchers due to its tremendous potential, there is renewed interest in the function of Tregs and in their clinical application in antitumor immunotherapy

Keywords： Regulatory T cells Cancer Immunotherapy

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords： triple-negative breast cancer immunotherapy targeted therapy

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Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 57-68 doi: 10.1007/s11684-019-0683-y

Abstract:

Lung cancer is the most common incident cancer and the leading cause of cancer death.In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-Ttumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancerThus, EGFRvIII is a potential antigen for targeted lung cancer therapy.EGFRvIII-CART showed significantly efficient antitumor activity against lung cancer cells expressing

Keywords： chimeric antigen receptor T cells epidermal growth factor receptor lung cancer immunotherapy tumor immunolog

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High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells

Synat Kang, Yanyan Li, Yifeng Bao, Yi Li

Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1

Abstract:

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapysub>157–165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancerinterferon-g and granzyme B production and in vitro cancera very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy

Keywords： cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT

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Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 12-23 doi: 10.1007/s11684-019-0685-9

Abstract:

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the lastThe efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmedfor treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancerachieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancercombining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer

Keywords： gastrointestinal cancer immune checkpoint inhibitor combination therapy

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsSome unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer

Keywords： cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review